Synergistic Antibacterial Activity of Ethanolic Extracts of Mondia whytei Roots and Physalis peruviana Leaves against S. aureus and E. coli

Aims: This work investigated the phytochemical constituents and synergistic antibacterial activity of ethanolic extracts Mondia whytei roots Physalis peruviana leaves.
 Study Design: study employed both qualitative quantitative methods.
 Place Duration Study: All research works were performed at Central Science Laboratories, Faculty science, Kyambogo University between September 2021 March 2022.
 Methodology: Standard methods followed for screening roots, leaves. The potential evaluated through agar well diffusion assay. bacteria strains cultured on Mueller-Hinton agar. Sterile cork borer (6 mm diameter) was used to create wells petri discs filled aseptically with 10 µl test extract (100 mg/ml) Chloramphenicol (0.5 as positive control. interaction combined assessed by determining their fractional inhibitory concentration (FIC) index.
 Results: Alkaloids, flavonoids, tannins, saponins, phenols found be present in extracts. Cardiac glycosides, terpenoids, anthraquinnones steroids only activities extract, leaves obtained following zone inhibitions; 19.20 ± 0.72 mm, 19.77 0.60 25.93 0.83 S. aureus 15.50 0.46 15.00 0.26 17.87 0.61 E.coli respectively, compared standard reference antibiotic 26.00 0.00 24.00 E. coli. MICs determined 0.1-100 mg/ml, FIC index from MIC values corresponding 0.5 (synergistic) 1.0 (additive) coli.
 Conclusion: results support traditional claims using selected plants treat bacterial infections. had low human pathogens, Hence, if these are unison, greater efficacy could achieved; further studies should done commercial antibiotics.